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. 2022 Jun 13;9:903608. doi: 10.3389/fmed.2022.903608

TABLE 3.

Cox proportional hazard model for the risk of autoimmune diseases.

Matched by age and sex
After PSM
HR (95% C.I.) p value HR (95% C.I.) p value
Group
Non-Optic neuritis Reference Reference
Optic neuritis 1.31 (1.00–1.72) 0.047 1.40 (1.05–1.87) 0.021
Age
<20 Reference Reference
20–39 1.04 (0.65–1.67) 0.862 1.41 (0.73–2.74) 0.306
40–64 1.71 (1.11–2.63) 0.015 2.13 (1.14–3.96) 0.017
≥65 1.56 (0.97–2.51) 0.069 1.91 (0.97–3.78) 0.062
Sex
Female Reference Reference
Male 0.69 (0.57–0.83) <0.001 0.70 (0.54–0.90) 0.006
Hypertension 1.22 (0.93–1.59) 0.152 1.04 (0.72–1.51) 0.821
Hyperlipidemia 1.00 (0.68–1.47) 0.999 0.70 (0.38–1.29) 0.248
Chronic liver disease 1.49 (1.01–2.19) 0.042 1.73 (1.10–2.70) 0.017
Chronic kidney disease 0.86 (0.27–2.70) 0.797 1.32 (0.42–4.17) 0.637
Diabetes 0.93 (0.65–1.34) 0.712 1.02 (0.62–1.66) 0.945
COPD 1.37 (0.86–2.19) 0.180 1.24 (0.68–2.27) 0.477
Cancer 1.06 (0.56–2.00) 0.851 0.90 (0.40–2.04) 0.803
Ischemic heart disease 0.86 (0.55–1.34) 0.507 0.78 (0.41–1.48) 0.452
Stroke 1.39 (0.88–2.18) 0.157 1.50 (0.86–2.63) 0.155
Corticosteroids 0.78 (0.62–0.98) 0.033 0.88 (0.67–1.15) 0.360

Adjusted for age, sex, hypertension, hyperlipidemia, chronic liver disease, chronic kidney disease, diabetes, COPD, cancer, ischemic heart disease, stroke, and corticosteroids. PSM, propensity score matching.