Table 2.
Univariable regression table for factors associated with PCSK9 level in ARDS.
| Univariable model | ||
|---|---|---|
| Characteristics | Beta (SE) | P |
| Age (years) | 0.0071 (0.00077) | 0.78 |
| Female sex [N (%)] | −0.027 (0.025) | 0.28 |
| Race [N (%)] | ||
| White | Ref | Ref |
| African–American | −0.057 (0.035) | 0.025 |
| Other | 0.030 (0.047) | 0.23 |
| Medical ICU [N (%)] | −0.074 (0.025) | 0.003 |
| Cause of ARDS [N (%)] | ||
| Sepsis | Ref | Ref |
| Trauma | 0.070 (0.089) | 0.008 |
| Transfusion | 0.010 (0.12) | 0.69 |
| Aspiration | 0.035 (0.053) | 0.24 |
| Pneumonia | 0.055 (0.034) | 0.088 |
| Other | 0.049 (0.070) | 0.073 |
| Shock | −0.051 (0.25) | 0.041 |
| Height (cm) | 0.013 (0.001) | 0.61 |
| Weight (kg) | 0.077 (0.00046) | 0.002 |
| BMI (kg/m2) | 0.077 (0.0014) | 0.002 |
| APACHE III score | −0.026 (0.00046) | 0.31 |
| Comorbidities [N (%)] | ||
| Chronic dialysis | −0.0071 (0.076) | 0.78 |
| AIDS | 0.029 (0.082) | 0.24 |
| Leukemia | 0.016 (0.066) | 0.53 |
| Lymphoma | −0.031 (0.12) | 0.21 |
| Solid tumor | −0.049 (0.078) | 0.052 |
| Immunodeficiency | 0.0099 (0.037) | 0.7 |
| Hepatic disease | −0.013 (0.12) | <0.001 |
| Cirrhosis | 0.024 (0.057) | <0.001 |
| Diabetes | 0.040 (0.028) | 0.12 |
| Hypertension | 0.054 (0.025) | 0.033 |
| Prior MI | 0.028 (0.057) | 0.27 |
| Prior heart failure | 0.023 (0.051) | 0.36 |
| Peripheral vascular disease | −0.034 (0.059) | 0.18 |
| Stroke/TIA | 0.021 (0.069) | 0.4 |
| Chronic pulmonary disease | −0.019 (0.035) | 0.46 |
| Laboratory evaluation | ||
| WBC, high (cells/mm3) | −0.062 (0.0001) | 0.01 |
| Platelets (cells/mm3) | 0.029 (0.00011) | 0.25 |
| Sodium, low (mEQ/L) | 0.050 (0.0023) | 0.048 |
| Potassium, high (mEQ/L) | −0.00034 (0.018) | 0.99 |
| Creatinine, high (mg/dL) | 0.016 (0.0088) | 0.52 |
| Glucose, high (mg/dL) | 0.088 (0.00015) | <0.0001 |
| Bicarbonate (mEQ/L) | 0.0532 (0.0024) | 0.035 |
| Sepsis [N (%)] | ||
| Primary diagnosis | −0.070 (0.37) | 0.01 |
| Secondary diagnosis | −0.043 (0.028) | 0.12 |
| Vasopressor use [N (%)] | 0.025 (0.025) | 0.29 |
| Temperature, high (degrees C) | 0.17 (0.012) | <0.001 |
| HR, high (beats per minute) | 0.042 (0.00054) | 0.092 |
| SBP, low (mmHg) | 0.046 (0.00079) | 0.07 |
| Urine out, day 0 (mL) | 0.040 (0.00001) | 0.12 |
| Fluid balance, day 0 (mL) | −0.015 (0.0001) | 0.54 |
| pH | 0.052 (0.15) | 0.042 |
| PaO2 (mmHg) | −0.026 (0.00035) | 0.3 |
| PaCO2 (mmHg) | −0.0022 (0.0012) | 0.93 |
| P/F ratio | −0.031 (0.00017) | 0.23 |