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. 2022 Jun 13;10:923769. doi: 10.3389/fcell.2022.923769

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Copyright © 2022 Paolino, Buratta, Mercuri, Pellegrino, Urbanelli, Emiliani, Bertuccini, Iosi, Huber, Brianti, Prezioso, Di Nicola, Federici and Lugini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phospholipid composition of EVs derived from plasma of HD, PSO and PSO treated with SCK, USTK and ADM. Lipid extracts from MV (A) and Exo (B) were analyzed by LC-MS. The amount of each PL class (sum of all detected species) is expressed as pg of lipids/µg of proteins. Data are reported as mean ± S.D. Statistically significant differences (p < 0.05) resulted by one-way ANOVA and Tukey’s post-hoc analysis; columns with different letters are significantly different (i.e. a vs. HD, b vs. PSO, c vs. SCK, d vs. USTK, e vs. ADM and π vs. all).