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. 2022 Jun 13;14:827900. doi: 10.3389/fnagi.2022.827900

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Copyright © 2022 Iakovou and Kourti.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The interplay between oxidative stress, SASP factors and accelerated aging. Several senescence-associated secretory phenotype (SASP) factors that contribute to accelerated aging are affected by the increased production of reactive oxygen species (ROS) and oxidative stress. SASP, senescence-associated secretory phenotype; mTOR, mammalian target of rapamycin; IL-1α, interleukin-1α; MMPs, matrix metalloproteinases; FOXO, Forkhead box; Ca⁺⁺-ATPase, calcium ATPase; SIRT1, sirtuin 1; SIRT6, sirtuin 6.