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. 2022 Jun 13;9:913883. doi: 10.3389/fnut.2022.913883

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Copyright © 2022 Li, Zheng, Zhang, Deng and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary of molecular mechanism of FTO-induced obesity, FTO protein structure and its binding with rhein. (A) Mechanism of FTO-induced obesity through regulating food intake, thermogenesis and adipogenesis. (B) Domain structures of FTO protein. Seven amino acid residues (Arg96, His231, Asp233, His307, Arg316, Arg322, and Ile370) are responsible for FTO activity. (C) Binding cavity and residues of FTO protein with rhein. The potential binding residues of FTO are highlighted using red font.