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. 2022 Jun 13;13:843732. doi: 10.3389/fphar.2022.843732

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Copyright © 2022 Martínez-Salgado, Sánchez-Juanes, López-Hernández and Muñoz-Félix.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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UUO modifies the renal ultrastructure after 3 days in Alk1 ^+/+ and Alk1 ^+/− mice. (A) Haematoxylin-eosin staining in SO, NO and O kidneys from Alk1 ^+/+ and Alk1 ^+/− mice show the typical features of the early stages of UUO such as tubular dilatation (asterisk), interstitial cell proliferation (arrow) or immune cell infiltration (arrowhead), being these features similar in O kidneys from Alk1 ^+/+ and Alk1 ^+/− mice. (B) Masson’s trichrome staining in SO, NO and O kidneys from Alk1 ^+/+ and Alk1 ^+/− mice showing lower ECM deposition (asterisk) in O kidneys from Alk1 ^+/− . Scale bar = 200 microns in both panels.