TABLE 1.
ALK1, BMP9 and Endoglin effects in tissue fibrosis.
| ALK1 | BMP9 | Endoglin | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Profibrotic effect | Antifibrotic effect | Profibrotic effect | Antifibrotic effect | Profibrotic effect | Antifibrotic effect | ||||||
| Ref. | Experimental model | Ref. | Experimental model | Ref. | Experimental model | Ref. | Experimental model | Ref. | Experimental model | Ref. | Experimental model |
| Scharpfenecker et al. (2011) | Kidney fibrosis by irradiation in Alk1 +/− mice | Muñoz-Félix et al. (2014a) | Unilateral Ureteral Obstruction (UUO) during 15 days in Alk1 +/− mice | Muñoz-Félix et al. (2016a) | Cultured mouse embryo fibroblasts | Morine et al. (2018) | Transverse aortic constriction (TAC) in Bmp9-KO mice. | Scharpfenecker et al. (2012) | Kidney fibrosis by irradiation in Eng +/− mice | Muñoz-Félix et al. (2016b) | UUO in S-Eng + mice (mice overexpressing human Short endoglin). |
| Morine et al. (2017b) | Deletion of ALK1 with conditional knockout mice | Morine et al. (2017a) | Transverse aortic constriction (TAC) in Alk1 +/− mice | Li et al. (2018) | CCl4 induced liver fibrosis Bile duct ligation (BDL) induced liver fibrosis | Desroches-Castan et al. (2019a) | Bmp9-KO mice | Scharpfenecker et al. (2009) | Kidney fibrosis by irradiation in Eng +/− mice | Pericacho et al. (2013) | Cutured dermal fibroblasts from Eng +/− mice |
| Wiercinska et al. (2006) | Cultured hepatic stellate cells | Muñoz-Félix et al. (2014b) | Cultured mouse embryo fibroblasts form Alk1 +/− mice | Breitkopf-Heinlein et al. (2017) | CCL4 and LPS induced liver fibrosis. BMP9 inactivated with adenoviruses | Desroches-Castan et al. (2019b) | Bmp9-KO mice | Scharpfenecker et al. (2013) | Kidney fibrosis by irradiation in Eng +/− mice | Velasco et al. (2008) | Cultured L6E9 rat myoblasts overexpressing L-Endoglin |
| Breitkopf-Heinlein et al. (2017) | CCL4 and LPS induced liver fibrosis. BMP9 inactivated with adenoviruses | Finnson et al. (2008) | Cultured human chondrocytes | Jiang et al. (2021) | Bleomycin-induced pulmonary fibrosis | Docherty et al. (2006b) | Kidney fibrosis induced by Ischaemia-reperfusion injury in Eng +/− mice | Finnson et al. (2010) | Cultured human chondrocytes | ||
| This current manuscript | UUO during 3 days in Alk1 +/− mice | Chen et al. (2017) | BMP9 treatment in neonatal rats | Kapur et al. (2012) | TAC in Eng +/− mice | Alzahrani et al. (2018) | Skin fibrosis induced by bleomycin | ||||
| Oujo et al. (2014) | UUO in L-Eng + mice (mice overexpressing human Large endoglin). | Obreo et al. (2004) | Cultured L6E9 myoblasts | ||||||||
| Gerrits et al. (2020) | cultured human renal myofibroblasts | Diez-Marques et al. (2002) | Cultured human mesangial cells | ||||||||
| Owen et al. (2020) | Patients with cirrhosis | Rodríguez-Barbero et al. (2006) | Cultured L6E9 myoblasts | ||||||||
| Morris et al. (2011) | Cultured scleroderma (SSc) fibroblasts | ||||||||||
| Meurer et al. (2011) | Cultured Hepatic stellate cells | ||||||||||