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. 2022 Jun 9;225(11):jeb243404. doi: 10.1242/jeb.243404

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© 2022. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — Inhibition of endocannabinoid signaling does not affect shock-induced sensitization. (A) Animals injected 25 µmol l⁻¹ THL (shocked N=10, control N=9) or 50 µmol l⁻¹ THL (shocked N=7, control N=8) are still sensitized to non-nociceptive stimuli by electroshocks (*P<0.001) and are no different from DMSO-injected (0; shocked N=9, control N=10) animals. (B) No shock-induced changes in response to nociceptive stimuli are observed in DMSO- or THL-injected animals. (C) Shock-induced sensitization to non-nociceptive stimuli are still observed in animals injected with SB366791 (shocked N=11, control N=12). Drug injection has no effect on responses to nociceptive stimuli in shocked animals (**P<0.005). Unshocked animals injected with SB366791 (controls) are not affected by the drug.