Table 4.
Genotoxic damage for ST and HB crosses with high [NIC]. Summary evaluation as not-genotoxic (-) or genotoxic (+) of each high NIC concentration treatment (NIC of 0.456 mM, 1.9 mM, 3.8 mM or 11.4 mM with no RES = 0.0 mM) and of the co-treatments (same NIC concentrations plus either 0.0004mM RES or 0.011mM RES) in the ST and the HB crosses. The co-treatment results were evaluated against the results for the ETOH dissolvent control for RES, the results for NIC (without RES) and the results for RES (without NIC). These comparisons were done with the non-parametric Mann-Whitney and Wilcoxon U-test P < 0.05 to provide additional information about which component of the co-treatment had the greatest effect.
| ST cross |
Control or treatment in corresponding cross | HB cross |
||||||
|---|---|---|---|---|---|---|---|---|
| Nicotine (mM) | Resveratrol (mM) | Resveratrol (mM) | Nicotine (mM) | |||||
| 0.0∗ | 0.0004 | 0.011 | 0.0∗ | 0.0004 | 0.011 | |||
| 0.456 | - | - | + | EtOH | - | + | - | 0.456 |
| - | - | NIC | - | - | ||||
| - | - | RES | - | - | ||||
| 1.9 | - | + | + | EtOH | - | - | - | 1.9 |
| + | + | NIC | - | - | ||||
| + | + | RES | ↓ | - | ||||
| 3.8 | - | - | + | EtOH | - | + | - | 3.8 |
| - | - | NIC | + | + | ||||
| - | - | RES | - | + | ||||
| 11.4 | + | + | - | EtOH | - |  |
11.4 | |
| + | ↓ | NIC | |
|
|
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| + | + | RES | - | |
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NIC was compared against Milli-Q water to determine genotoxicity. + signifies an increase with P < 0.05 ↓ signifies a decrease with P < 0.05; - signifies that P > 0.05, signifies that treatment was lethal with no survivors.