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. 2022 Jun 18;28:100413. doi: 10.1016/j.ensci.2022.100413

Fig. 1.

Fig. 1

MRI (A), macroscopic (B), and microscopic (C-U) findings.

A: Sagittal T2-weighted images on lumbar magnetic resonance imaging show a small solitary intradural cauda equina mass at the L3 level. B: Macroscopic findings of the spinal cord show a small nodule (arrowhead) within the left L5 root. C-D: At a low magnification of the motor cortex, hematoxylin and eosin (HE) staining shows mild neuronal loss and reactive gliosis in the motor cortex (C). Klüver-Barrera (KB) staining shows no apparent myelin pallor in the white matter (D). E: KB staining of a cross-section of the thoracic spinal cord shows right-dominant myelinated fiber loss in the corticospinal tract. F: Neuronal loss and gliosis are shown in the anterior horn cells of the lumbar spinal cord. G-H: In the anterior horn cells of the cervical spinal cord, a Bunina body (G) and round hyalin inclusion (H) are identified by HE staining. I: The number of neurons in the intermediolateral nucleus of thoracic spinal cord is preserved. J: Onuf's nucleus in the anterior horn cells of the sacral spinal cord is well preserved. K: A p-TDP-43-immunopositive inclusion is found in the cytoplasm of an anterior horn cell of the lumbar spinal cord. L: A p-TDP-43 immunoreactive glial cytoplasmic inclusion is present in the white matter of the motor cortex. M-N: In the hypoglossal nucleus (M) and hippocampal granular cell layer (N), p-TDP-43-positive neuronal cytoplasmic inclusions are observed. O-Q: A small number of p-TDP-43-immunoreactive deposits are observed in the lumbar (O—P) and cervical anterior roots (Q, arrowhead). R-S: p-TDP-43 immunoreactivity is seen in the peripheral nerves in the thoracic sympathetic ganglia (R, arrowheads), but not in the neurons of thoracic sympathetic ganglia (S). T: p-TDP-43-immunoreactive deposits are absent in Auerbach's myenteric nerve plexus of the rectum. U: Histopathology of the tumor shows fascicular proliferation of spindle-shaped or oval-shaped cells. Scale bars = 10 μm (G-H, K-L, N-Q), 50 μm (F, I-J, M, R-U), and 200 μm (C-E).