Table 1.
Summary of clinical findings.
| Clinical sign | Duration to appearance (months) | ||
|---|---|---|---|
| Initial symptom | Weight loss | + | 0 |
| Autonomic symptoms | Constipation | + | 9 |
| Fecal incontinence | + | 10 | |
| Urinary incontinence | + | 10 | |
| Tachycardia | + | 11 | |
| Urinary retention | + | 12 | |
| Increased sweating | ー | ||
| Reduced sweating | ー | ||
| Heat intolerance | ー | ||
| Blurred vision | ー | ||
| Orthostatic hypotension | ー | ||
| Orthostatic dizziness | ー | ||
| Blood pressure fluctuations | ー | ||
| Motor symptoms | Dyspnea | + | 9 |
| Dysphagia | + | 10 | |
| Upper limb weakness | + | 11 | |
| Wheelchair | + | 12 | |
| Dysarthria | + | 14 | |
| Lower limb weakness | + | 14 | |
| Bedridden | + | 15 | |