Table 2.
Summary of neuropathological findings.
| Anatomical region | p-TDP-43 inclusions | |||
|---|---|---|---|---|
| Frontal lobe | Cortex | NL | + | + |
| White matter | GL | + | ー | |
| Striatum | Caudate nucleus | NL/GL | ー/+ | + |
| Putamen | NL/GL | ー/+ | + | |
| Thalamus | NL/GL | ー/+ | + | |
| Hypothalamus | NL/GL | NA/NA | NA | |
| Midbrain | Oculomotor nucleus | NL/GL | ー/ー | + |
| Substantia nigra | NL/GL | ー/ー | ー | |
| Periaqueductal gray | NL/GL | ー/+ | + | |
| Pons | Locus coeruleus | NL/GL | ー/ー | + |
| Lateral dorsal tegmental nucleus | NL/GL | ー/ー | ー | |
| Pontine nuclei | NL/GL | ー/ー | + | |
| Medulla oblongata | Hypoglossal nucleus | NL/GL | +/+ | + |
| Dorsal vagal nucleus | NL/GL | ー/ー | + | |
| Ambiguous nucleus | NL/GL | ー/ー | ー | |
| Solitary tract nucleus | NL/GL | ー/ー | ー | |
| Inferior olivary nucleus | NL/GL | ー/ー | + | |
| Cerebellum | Cerebellar cortex | NL/GL | ー/ー | ー |
| Dentate nucleus | NL/GL | ー/+ | ー | |
| Cervical cord | Anterior horn cells | NL/GL | +/+ | + |
| Lateral corticospinal tract | Myel.f.loss | + | ー | |
| Anterior corticospinal tract | Myel.f.loss | + | ー | |
| Posterior funiculus | Myel.f.loss | ー | ー | |
| Posterior spinocerebellar tract | Myel.f.loss | ー | ー | |
| Thoracic/Lumbar cord | Anterior horn cells | NL/GL | +/+ | + |
| Intermediolateral nucleus | NL/GL | ー/ー | + | |
| Lateral corticospinal tract | Myel.f.loss | + | ー | |
| Anterior corticospinal tract | Myel.f.loss | + | ー | |
| Posterior funiculus | Myel.f.loss | ー | ー | |
| Posterior spinocerebellar tract | Myel.f.loss | ー | ー | |
| Sacral cord | Intermediolateral nucleus | NL/GL | ー/ー | ー |
| Onuf's nucleus | NL/GL | ー/ー | ー | |
| Sympathetic ganglia | NL/GL | ー/ー | ー | |
p-TDP-43: phosphorylated TAR DNA binding protein 43 kDa; NL: neuronal loss; GL: gliosis; NA: not available; +: present; −: none; Myel: Myelinated; f: fiber.