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. 2022 Jun 21;77:100069. doi: 10.1016/j.clinsp.2022.100069

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© 2022 HCFMUSP. Published by Elsevier España, S.L.U.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig 3 — miR-146b inhibits FGL2 in IBD-derived macrophages. (A) TargetScan database and GSE42911 dataset were used to screen the target gene of miR-146b. (B) The expression of intersected genes in miR-146b-overexpressed cells was examined by q-PCR (C and D) The expression of FGL2 in IBD mice (C) and LPS-induced macrophages (D) was determined by q-PCR and Western blotting. (E) FGL2 expression in miR-146b-overexpressed or miR-146b-depleted macrophages was determined by Western blotting. (F and G) The correlation between miR-146b and FGL2 was investigated by Dual Luciferase reporter (F) and RIP (G) in 293T cells.