Fig. 6.

miR-146b ameliorates the inflammation phenotypes and M1 macrophage polarization of IBD mice in vivo. MiR-146b agomir was injected through the tail vein into IBD mice, and miR-146b expression in colon tissues was determined by q-PCR (A). The body weight (B), DAI scores (C), colon length (D) and the pathological changes (E) in IBD mice. The levels of inflammation-related factors were detected by ELISA assay (F), and M1 macrophage polarization-related indicators were determined by Western blotting (G).