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. 2022 Mar 3;6(7):1753–1763. doi: 10.1002/hep4.1918

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© 2022 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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The HelioLiver Test Workflow. Blood specimens were collected from patients and then assayed for alpha‐fetoprotein (AFP), Lens culinaris agglutinin‐reactive AFP (AFP‐L3%), and des‐gamma‐carboxy prothrombin (DCP) by using immunoassays, and for cell‐free DNA (cfDNA) methylation patterns of 28 genomic regions by using a cfDNA Methylation Assay. The data for each assay were then input into a diagnostic algorithm with the patient’s age and sex, to generate a qualitative (positive/negative) test result