FIG. 1.

H2‐Db expression protects animals from lethal LCMV‐induced liver pathology. (A) WT and H2‐D1^−/− mice were infected with 2 × 10⁴ pfu of LCMV Docile. (A) Blood glucose concentration was monitored (starting with n = 7 animals). (B) WT, H2‐D1^−/− , and H2‐K1^−/− mice were infected with 2 × 10⁴ pfu of LCMV Docile, and survival was monitored (n = 6‐7). (C) WT and H2‐D1^−/− mice were infected with 2 × 10⁴ pfu of LCMV Docile. At day 9 following infection, ALT, AST, and LDH activity in the serum of control and H2‐D1^−/− mice was determined (n = 6). Error bars show SEM. *P < 0.05, **P < 0.01, and ***P < 0.001, between the indicated groups).