TABLE 1.
Pathology Grading Criteria
| Fibrosis Stage | F Score | Inflammation | L Score |
|---|---|---|---|
| No fibrosis | 0 | <0.5 | 0 |
| Early fibrous expansion emanating from some portal areas ± short fibrous septa; increased short, disorganized fibrous septa along some sinusoids | 1 | 0.5 ‐ 1.0 | 1 |
| Fibrous expansion emanating from most portal areas; network of loose fibrous septae coalescing along numerous sinusoids | 2 | 1.0 ‐ 2.0 | 2 |
| Fibrous expansion of portal areas with occasional early portal‐portal bridging, which often coalesces with sinusoidal fibrous network (most prominent in liver lobule zone I) | 3 | >2.0 | 3 |
| Fibrous expansion of portal areas with common portal‐portal bridging and some portal‐central vein bridging, which coalesces with sinusoidal fibrosis most prominent in liver lobule zones I and II | 4 | Steatosis (micro/macro) Hypertrophy | S score |
| More prominent bridging, occasional nodule formation (incomplete cirrhosis) | 5 | <5% | 0 |
| Cirrhosis with marked bridging and nodules | 6 | 5%‐33% (periportal) | 1 |
| 34%‐66% (periportal) | 2 | ||
| >66% (periportal) | 3 | ||
| >66% (diffuse) | 4 |