Table 4.

In-hospital outcomes in young and old patients with ischaemic stroke treated with IV tPA

Outcome	Rate of outcomes	aOR (95% CI) from model 1	aOR (95% CI) from model 2	aOR (95% CI) from model 3	aOR (95% CI) from model 4
sICH	414/48 141 (0.9)
Young adults	26/5044 (0.5)	0.57 (0.38 to 0.85)	0.74 (0.49 to 1.11)	0.77 (0.5 to 1.18)	0.79 (0.52 to 1.20)
Old adults	388/43 097 (0.9)	1.00	1.00	1.00	1.00
In-hospital mortality	579/48 141 (1.2)
Young adults	24/5044 (0.5)	0.37 (0.24 to 0.55)	0.54 (0.35 to 0.82)	0.70 (0.46 to 1.09)	0.65 (0.43 to 1.00)
Old adults	555/43 097 (1.3)	1.00	1.00	1.00	1.00
Independent ambulation at discharge	26 175/48 141 (54.4)
Young adults	3079/5044 (61.0)	1.36 (1.28 to 1.44)	1.15 (1.08 to 1.22)	1.00 (0.93 to 1.08)	1.02 (0.96 to 1.10)
Old adults	23 096/43 097 (53.6)	1.00	1.00	1.00	1.00

Model 1: logistic regression model without adjustment.

Model 2: adjusted for gender, insurance, BMI, previous stroke/TIA, previous CAD/prior MI, diabetes, hypertension, have smoking experience or behaviour, atrial fibrillation/flutter, glycated haemoglobin, diastolic blood pressure, systolic blood pressure, hypoglycaemic drugs, antihypertensive drugs, antiplatelet drugs and lipid-lowering drugs.

Model 3: adjusted for in-hospital NIHSS score, gender, insurance, BMI, previous stroke/TIA, previous CAD/prior MI, diabetes, hypertension, have smoking experience or behaviour, atrial fibrillation/flutter, glycated haemoglobin, diastolic blood pressure, blood pressure, hypoglycaemic drugs, antihypertensive drugs, antiplatelet drugs and lipid-lowering drugs. Patients (n=2503) with missing values on NIHSS score were not included in this analysis.

Model 4: results from multiple imputation.

aOR, adjusted OR; BMI, body mass index; CAD, coronary artery disease; MI, myocardial infarction; NIHSS, National Institutes of Health Stroke Scale; sICH, symptomatic intracranial haemorrhage; IV tPA, intravenous tissue plasminogen activator.