Table 2.

Moderating effect of each CR proxy on the relationship between global Aβ and cognition

Model term	B	SE	β	p
Model 1
Education	1.14	0.13	0.35	<.001b
Global Aβ	−17.94	1.44	−0.52	<.001b
Education × global Aβ	0.80	0.28	0.11	.004a
Model 2
pIQ	0.55	0.06	0.39	<.001b
Global Aβ	−16.14	1.41	−0.46	<.001b
pIQ × global Aβ	0.07	0.10	0.03	.45
Model 3
OC	2.12	0.49	0.19	<.001b
Global Aβ	−17.55	1.55	−0.50	<.001b
OC × global Aβ	1.83	0.97	0.07	.061
Model 4
LCA	5.85	0.89	0.26	<.001b
Global Aβ	−17.01	1.52	−0.49	<.001b
LCA × global Aβ	2.38	2.01	0.05	.24

Note: Age, sex, and APOE4 carrier status were treated as covariates. B: unstandardized coefficient, β: standardized coefficient.

Key: CR, cognitive reserve; Aβ, amyloid-beta; pIQ premorbid Intelligence Quotient; OC, occupational complexity; LCA, lifetime cognitive activity; SE, standard error; APOE4, apolipoprotein E ε4.

^ap < 0.01.

^bp < 0.001.