Table 3.

Moderating effect of each CR proxy on the relationship between AD-CM and cognition

Model term	B	SE	β	p
Model 1
Education	1.04	0.14	0.32	<.001^b
AD-CM	38.84	4.37	0.36	<.001^b
Education × AD-CM	−2.23	1.00	−0.09	.026^a
Model 2
pIQ	0.53	0.06	0.38	<.001^b
AD-CM	34.24	4.20	0.32	<.001^b
pIQ × AD-CM	−0.91	0.38	−0.10	.016^a
Model 3
OC	1.85	0.52	0.17	<.001^b
AD-CM	38.75	4.66	0.36	<.001^b
OC × AD-CM	−2.77	3.25	−0.04	.40
Model 4
LCA	5.52	0.94	0.25	<.001^b
AD-CM	36.92	4.48	0.35	<.001^b
LCA × AD-CM	−15.63	6.33	−0.10	.014^a

Note: Age, sex, and APOE4 carrier status were treated as covariates. B: unstandardized coefficient, β: standardized coefficient.

Key: CR, cognitive reserve; AD-CM, AD-signature region cerebral glucose metabolism; pIQ premorbid Intelligence Quotient; OC, occupational complexity; LCA, lifetime cognitive activity; SE, standard error; APOE4, apolipoprotein E ε4.

p < 0.05.

p < 0.001.