Table 4.

Moderating effect of each CR proxy on the relationship between AD-CT and cognition

Model term	B	SE	β	p
Model 1
Education	0.98	0.14	0.30	<.001b
AD-CT	39.74	3.41	0.51	<.001b
Education × AD-CT	−0.61	0.63	−0.04	.33
Model 2
pIQ	0.55	0.05	0.40	<.001b
AD-CT	37.27	3.24	0.48	<.001b
pIQ × AD-CT	−0.18	0.24	−0.03	.45
Model 3
OC	1.93	0.49	0.17	<.001b
AD-CT	39.18	3.56	0.50	<.001b
OC × AD-CT	−6.28	2.19	−0.11	.004a
Model 4
LCA	5.81	0.89	0.26	<.001b
AD-CT	40.03	3.50	0.51	<.001b
LCA × AD-CT	0.59	4.20	0.01	.89

Note: Age, sex, and APOE4 carrier status were treated as covariates. B: unstandardized coefficient, β: standardized coefficient.

Key: CR, cognitive reserve; AD-CT, AD-signature region cortical thickness; pIQ, premorbid Intelligence Quotient; OC, occupational complexity; LCA, lifetime cognitive activity; SE, standard error; APOE4, apolipoprotein E ε4.

^ap < 0.01.

^bp < 0.001.