Table 2.
Research gaps in adult FPIES.
| Patient Presentation | |
| •Population-based studies to identify incidence and prevalence | |
| • Are there population differences between adults with de novo FPIES and young adults with persistent FPIES from childhood? | |
| Food Triggers | |
| • Frequency of FPIES to multiple foods in adults? | |
| • Are there patterns of cross-reactive allergens in adults with FPIES (i.e.,: as seen with milk and soy in children)? | |
| Diagnosis | |
| • Uniform diagnostic criteria based on adult symptomatology | |
| • Screening studies to identify biomarkers or diagnostic assays | |
| Management | |
| • Optimal oral food challenge protocols | |
| • Study safety and efficacy of antiemetics | |
| • Identify psychosocial impact of FPIES for adult patients | |
| Prognosis | |
| • Prospective studies with food challenges to determine if tolerance occurs | |
| Etiology | |
| • Mechanistic studies of disease pathogenesis and development of allergen tolerance |