Skip to main content
. 2022 Jun 2;65(12):8191–8207. doi: 10.1021/acs.jmedchem.1c02175

Scheme 1. Synthesis of 2-Substituted Pyrimidine Benzimidazolones and Tricyclic Quinolinones from Tables 1–3.

Scheme 1

Reagents and conditions: (a) cyclic amine, DIPEA, NMP, 140 °C, 1–2 h; (b) 2,4,5-trichloropyrimidine, DIPEA, NMP, 140 °C, 1 h; and (c) cyclic amine, DIPEA, NMP or MeCN, 80–140 °C, 1–18 h.