Table 2. Structure–Activity Relationships of Tricyclic Quinolinone Degraders.

^aIndicates n = 1.

^bIndicates n = 2.

^cData represent the geometric mean of at least three replicates. See Tables S1 and S2 for full statistics.

^dMeasured log D determined using the Chrom log D method.

^eKinetic solubility measured by NMR in HEPES buffer at pH 8, containing 4% DMSO.

^fIndicates solubility measured by HPLC in PBS buffer and 1% DMSO at pH 7.4.

^gCompound exists as a single unknown enantiomer.