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. 2022 Jun 2;65(12):8191–8207. doi: 10.1021/acs.jmedchem.1c02175

Table 3. Structure–Activity Relationships of Monosubstituted Piperidine Degraders.

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a

Indicates n = 2.

b

Data represent the geometric mean of at least three replicates. See Supporting Information Tables S1 and S2 for full statistics.

c

Measured log D determined using the Chrom log D method.

d

Kinetic solubility measured by NMR in HEPES buffer at pH 8, containing 4% DMSO.