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. 2021 Oct 28;81(24):6259–6272. doi: 10.1158/0008-5472.CAN-21-1256

Figure 6.

Figure 6. The growth of 20 ER+ PDX tumors in xenografted mice in the absence and presence of E2. Volumes of 20 ER+ PDX tumors were measured in ovariectomized SCID/beige mice supplemented with or without 8 μg/mL E2 in the drinking water (mean ± SEM; n = 7–16 per PDX line per arm). PDX tumors were categorized based on ESR1 status (mutations listed or wild-type, wt) and E2 dependency for growth (E2 independent, E2 suppressed, E2 partially dependent, and E2 dependent).

The growth of 20 ER+ PDX tumors in xenografted mice in the absence and presence of E2. Volumes of 20 ER+ PDX tumors were measured in ovariectomized SCID/beige mice supplemented with or without 8 μg/mL E2 in the drinking water (mean ± SEM; n = 7–16 per PDX line per arm). PDX tumors were categorized based on ESR1 status (mutations listed or wild-type, wt) and E2 dependency for growth (E2 independent, E2 suppressed, E2 partially dependent, and E2 dependent).