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. 2022 Jun 3;13:904536. doi: 10.3389/fgene.2022.904536

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Copyright © 2022 Yao, Liu, Yang, Li, Li, Zhang, Yang, Zhang, Cui and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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scRNA-seq identified the cellular components in MIBC and inferred malignant epithelial cells (A,B) t-SNE plot showing clustering information in MIBC (C) FeaturePlot was used to demonstrate the identity of epithelial cells through the expression of a well-known specific marker (EPCAM) (D) Heatmap showing the chromosomal landscape of inferred large-scale copy number variations (inferCNVs) distinguishing individual tumor (malignant) cells from nontumor cells. Red box: Amplifications of CNV, Blue box: Deletions of CNV.