Fig. 5.

Chloroquine potentiates the antitumoral activity of chemotherapy and PI3K/AKT inhibitors combination in TNBC cell lines a-c Daily exposure for 10 days to triple combination of low doses of CQ (58 nM-1 µM), paclitaxel (0,5 nM), ipatasertib (1 µM) or taselisib (1 µM) exposure, prevent clonogenic formation in MDAMB231 and MDAMB468 cell lines. Representative experiments, similar experiments yeld similar results b-d Triple combination of low doses of CQ (1 µM), paclitaxel (1 nM), ipatasertib (1–10 µM) or taselisib exposure, to the indicated treatments, induces the inhibition of cell proliferation in MDAMB231 and MDAMB468 cell lines, measured by SRB assay after 72 h and expressed as % of CTL. Each experiment is representative of three independent experiments. Statistically significant results are reported (*** indicates P < 0.0005, ** indicates P < 0.005 and * indicates P < 0.05)