Table 1.

Genetic background of breast cancer cell lines and antiproliferative effect of drugs alone

CELL LINE	ER amplification	HER2 amplification	Mutations	Additional features	IPATASERTIB IC50	TASELISIB IC50
MDAMB231	−	−	KRAS/B-RAF	p53 NF2 p16 CDKN2 p14 CDKN2A	70 µM	25 µM
MDAMB468	−	−	PTEN null	EGFR ampification p53 SMAD4 RB1	5 µM	2.5 µM
MCF7	+	−	PI3KCA	p16 CDKN2 p14 CDKN2A	10 µM	500 nM
SKBR3	−	+	wt	p53	500 nM	50 nM
MDAMB361	+	+	PI3KCA	NA	1 µM	100 nM