Table 2:
Description of the cohort at index
| No. (%)* | ||||||
|---|---|---|---|---|---|---|
| Total (N = 13,406) | C282Y homozygote (n = 527) | Wild type (n = 12,879) | p-value | Standardized difference† | ||
| Demographics | ||||||
| Age at index date, years | ||||||
| Mean (SD) | 49.00 (13.78) | 48.14 (15.61) | 49.04 (13.70) | 0.145 | 6% | |
| Median (IQR) | 48 (39–58) | 49 (38–58) | 48 (39–58) | 0.811 | 1% | |
| <30 | 2,734 (20.4) | 81 (15.4) | 2,653 (20.6) | <0.001 | 13% | |
| 30–39 | 3,615 (27.0) | 128 (24.3) | 3,487 (27.1) | 6% | ||
| 40–49 | 3,002 (22.4) | 128 (24.3) | 2,874 (22.3) | 5% | ||
| 50–59 | 3,100 (23.1) | 126 (24.0) | 2,974 (23.1) | 2% | ||
| ≥60 | 950 (7.1) | 62 (11.8) | 888 (6.9) | 17% | ||
| Sex = male | 5,512 (41.1) | 309 (58.6) | 5,203 (40.4) | <0.001 | ||
| Comorbidities and health history | ||||||
| Congestive heart failure | 223 (1.7) | 12 (2.3) | 211 (1.6) | 0.256 | 5% | |
| Diabetes | 1,268 (9.5) | 61 (11.6) | 1,207 (9.4) | 0.085 | 7% | |
| Rheumatoid arthritis | 164 (1.2) | 6 (1.1) | 158 (1.2) | 0.863 | 1% | |
| Osteoarthritis‡ | 1,478 (11.0) | 84 (15.9) | 1,394 (10.8) | <0.001 | 15% | |
| Recent osteoporotic fracture§ | 168 (1.3) | 15 (2.8) | 153 (1.2) | <.001 | 12% | |
| Chronic liver disease§ | 891 (6.6) | 186 (35.3) | 705 (5.5) | <0.001 | 80% | |
| Pneumonia§ | 582 (4.3) | 37 (7.0) | 545 (4.2) | 0.002 | 12% | |
| Dementia | NR | ≤5 | 25 (0.2) | 0.985 | 0% | |
| Parkinson's disease§ | NR | ≤5 | 42 (0.3) | 0.83 | 1% | |
| Cirrhosis‡ | 77 (0.6) | 20 (3.8) | 57 (0.4) | <0.001 | 23% | |
* Unless otherwise specified
† A standard difference >10% is statistically significant (25)
‡ Evidence within 5 years prior to index
§ Evidence within 3 years prior to index
IQR = Interquartile range; NR = Not recorded