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. 2022 Jun 27;20:303. doi: 10.1186/s12951-022-01505-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Integrated bioinformatics analysis between Chinese herb Burdock and OA. A The intersected gene targets between the medicine (Burdock) and the disease (OA). B Proteins and proteins interaction network of the 33 identified targets. C The rank of potential key proteins according to the nodes number. D Medicine-Ingredient-Target-Disease (M-I-T-D) network model. E The structure of the Burdock extract, arctiin (ARC). F GO enrichment analysis based on the differentially expressed genes (DEGs). G KEGG pathways analysis in accordance with DEGs