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. 2022 Jun 27;20:303. doi: 10.1186/s12951-022-01505-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — RNA sequencing analysis between CTRL and arctiin-treated chondrocytes. A The heat map showed the differentially expressed genes (DEGs) between CTRL and ARC groups (n = 3). B, C GO enrichment analysis indicated the up-regulated or down-regulated biological processes according to the DEGs. D KEGG enrichment analysis revealed the up-regulated or down-regulated pathways. E, F GSEA enrichment analysis identified the potential KEGG or Reactome pathways. G Proteins and proteins interaction (PPI) based on the DEGs. H Transcriptional factors (TFs) distribution analysis between CTRL and arctiin-treated group