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. 2022 Jun 27;20:303. doi: 10.1186/s12951-022-01505-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Characteristics of the fabricated GG-CD@ARC biological glue. A Representative images of the surface morphology using a scanning electron microscope (SEM). B Fourier transform infrared (FTIR) showed a successful grafting reaction between gellan gum and cyclodextrin. C The crystal form of composites was detected using X-ray powder diffraction (XRD). D The cumulative release curves of arctiin at each 2-week time-point (n = 6). E The impact of each complex on cell proliferation was quantified using the CCK-8 method (n = 6). F The viability of cells cultured with leachate and stained with Live/Dead assays (n = 3). Values represent mean ± SD. Statistically significant differences are indicated by * where p < 0.05, ** where p < 0.01, *** where p < 0.001 and **** where p < 0.0001 between the indicated groups