Fig. 1.

Both high-fat diet and leptin knockout significant aggravated depressive-like behaviors post-chronic stress exposure. Diagram of CSDS model mice establishment (A) and experimental design (B). To assess the behavioral changes among different mice model, social interaction (C) was performed under aggressor present and absent. D The anxiety behaviors of mice were evaluated by open-field test and elevated plus-maze, and E depressive behaviors of mice were investigated by tail suspension test, forced swim test, and sucrose preference test. (ND represented as normal diet, HFD represented as high-fat diet, LM represented as littermate mice, and ob/ob represented as obesity transgenic mice; *p < 0.05, ***p < 0.001 compared with ND mice; ^#p < 0.05 compared with LM mice)