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. 2022 Jun 27;19:166. doi: 10.1186/s12974-022-02529-4

Fig. 6.

Fig. 6

mPFC injection of GfaABC1D-hM4Di-AAV and CNO i.p treatment significantly inhibited astrocytes reactivity. Diagram of experimental design (A). Astrocyte response was detected by investigating activation related genes expression of isolated astrocyte (B). Astrocyte morphology was measured by calculating (C) spreading area and number of interactions. The level of D-serine, glutamate, ATP, and GABA were also assessed in microdialysate from mPFC (D). (*p < 0.05 compared with saline-treated mice)