Table 4.
Reclassification and discrimination statistics for clinical outcomes by adding inflammatory markers of IL-6 and YKL-40 to clinical risk scores
| Outcomes | Model | AUC | NRI,% | ||
|---|---|---|---|---|---|
| Estimate (95% CI) | P value | Estimate (95% CI) | P value | ||
| Stroke recurrence | ESRS | 0.54 (0.52–0.55) | – | Reference | – |
| ESSEN + IL-6 + YKL-40 | 0.57 (0.55–0.58) | < 0.0001 | 19.0 (12.7–25.4) | < 0.0001 | |
| mRS (2–6) | THRIVE score | 0.57 (0.56–0.58) | – | Reference | – |
| THRIVE Score + IL-6 + YKL-40 | 0.64 (0.63–0.66) | < 0.0001 | 33.0 (28.4–37.6) | < 0.0001 | |
AUC area under the curve, CI confidence interval, NRI net reclassification index, ESRS Essen Stroke Risk Score, THRIVE Score totaled health risks in vascular events score