Title {1}	The High-volume Haemodiafiltration vs High-flux Haemodialysis Registry Trial (H4RT): a multi-centre, unblinded, randomised, parallel-group, superiority study to compare the effectiveness and cost-effectiveness of high-volume haemodiafiltration and high-flux haemodialysis in people with kidney failure on maintenance dialysis using linkage to routine healthcare databases for outcomes.
Trial registration {2a and 2b}.	ISRCTN10997319. Registered on 10th October 2017. Prospectively registered.
Protocol version {3}	Version 8, 3 May 2022
Funding{4}	National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Programme, project number 15/80/52
Author details {5a}	1 Population Health Sciences, Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK 2 Renal unit, Southmead Hospital, North Bristol NHS Trust, Bristol, BS10 5NB, UK 3 Bristol Trials Centre, 1-5 Whiteladies Road, Bristol Medical School, University of Bristol, Bristol, BS8 1NU, UK 4 Research and Innovation, Southmead Hospital, Bristol, BS10 5NB, UK 5 UCL Department of Renal Medicine, Royal Free Hospital, University College London, London, England 6 Renal Unit, Lister Hospital, East and North Hertfordshire NHS Trust, Coreys Mill Lane, Coreys Mill Ln, Stevenage, SG1 4AB, UK 7 Renal Unit, Manchester University Hospitals NHS Trust, Manchester, UK 8 George Institute for Global Health, Sydney, Australia 9 Public and patient involvement representative, Bristol, UK
Name and contact information for the trial sponsor {5b}	North Bristol NHS Trust, Southmead Hospital, Bristol, UK. BS10 5NB researchsponsor@nbt.nhs.uk
Role of sponsor {5c}	The sponsor played no part in study design and will play no part in the collection, management, analysis, and interpretation of data. The sponsor is however responsible for overall oversight of the trial. Drafts of all reports will be shared with the Sponsor for approval prior to submission for publication.