Comparison 1. Any pharmaceutical treatment versus placebo or no treatment.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Complete relief of heartburn	2	256	Risk Ratio (M‐H, Fixed, 95% CI)	1.85 [1.36, 2.50]
2 Partial relief of heartburn	2	256	Risk Ratio (M‐H, Random, 95% CI)	1.35 [0.38, 4.76]
3 Side effects	2	256	Risk Ratio (M‐H, Fixed, 95% CI)	0.63 [0.21, 1.89]