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Correlations between in vitro 5-HT1AR affinity (Ki values) and potency to produce lower lip retraction and antinociception. Ordinates: (left panel) ED50 value in μmol/kg (i.p.) to produce lower lip retraction; (right panel) ED50 value in μmol/kg (i.v.) to produce antinociception. Abscissae: Ki values at 5-HT1ARs in nM. (Left panel) The R2 value was 0.807 (P = 0.0508). (Lower panels) The R2 values were 0.9025 (P = 0.142).
