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. Author manuscript; available in PMC: 2022 Jun 27.
Published in final edited form as: Biochem Pharmacol. 2021 Sep 17;193:114769. doi: 10.1016/j.bcp.2021.114769

Figure 7.

Figure 7.

Synthetic evolution of pH-insensitive formers of macromolecule-sized pores. A. The same library and assay described in Figure 6 were used to measure release of small and large molecules, except that both assays were done at pH 7. Highly potent macromolecular poration gives the outliers in the upper right. B. The macrolittins are similar to the pHD peptides except that they have three acidic residues out of six possible.