TABLE 5.
Odds ratios and 95% CIs for the association between RORA rs2028122 genotype and PD, separated by sleep duration and RORA rs2028122 genotype, respectively.
| Sleep duration |
||||||
| rs2028122 genotype | Normal sleep duration OR (95% CI) |
p | Short sleep duration OR (95% CI) |
p | Long sleep duration OR (95% CI) |
p |
| (a) | ||||||
| AA | 1 | 1 | 1 | |||
| AG | 0.96 (0.81–1.13) | 0.60 | 1.13 (0.87–1.47) | 0.35 | 1.67 (1.09–2.55) | 0.019 |
| GG | 1.06 (0.89–1.26) | 0.51 | 1.27 (0.97–1.66) | 0.082 | 1.50 (0.97–2.33) | 0.069 |
|
| ||||||
|
rs2028122 genotype
|
||||||
| Sleep duration categories | AA OR (95% CI) | p | AG OR (95% CI) | p | GG OR (95% CI) | p |
|
| ||||||
| (b) | ||||||
| Normal sleep duration | 1 | 1 | 1 | |||
| Short sleep duration | 0.99 (0.75–1.33) | 0.97 | 1.28 (1.09–1.50) | 0.003 | 1.26 (1.06–1.50) | 0.009 |
| Long sleep duration | 0.79 (0.52–1.20) | 0.27 | 1.38 (1.13–1.69) | 0.001 | 1.11 (0.89–1.40) | 0.36 |
Stratification analysis was performed for all sample in this table. (a) Odds ratios and 95% CIs for the association between RORA rs2028122 genotype and PD, separated by sleep duration. (b) Odds ratios and 95% CIs for the association between sleep duration and Parkinson’s disease, separated by the RORA rs2028122 genotype. Logistic regression analysis was adjusted for age, sex, education, ethnicity, BMI, overall health rating, alcohol intake frequency, employment, IPAQ, summed MET minutes per week for all activity, self-reported sleep duration, getting up easily in morning, chronotype, narcolepsy, insomnia, snoring, and rs2028122 genotype. CI, confidence interval; ORs, odds ratios.