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. 2022 Jun 27;38(Suppl 1):i369–i377. doi: 10.1093/bioinformatics/btac231

Table 4.

Negative regulation feasibility and structure

Reactome
accumulation conservation
0th-order factory instances (min-edge and min-source) 3955 1649
1st-order factory instances (min-edge and min-source) 3933 1640
2nd-order factory instances (min-edge) 3671 1614
Instances where 1st- worse than 0th-order (min-edge) 83 6
Instances where 1st- worse than 0th-order (min-source) 14 0
Instances where 2nd- worse than 1st-order (min-edge) 11 4
median max median max
0th- to 1st-order factory length change 1 4 2 3
0th- to 1st-order factory source change 1 4 0 0
1st- to 2nd-order factory length change 3 6 3 4
Number of 2nd-order iterations 1 554 1 285