Table 3.

Top Genes for PM2.5 Exposure in CANDLE.

							GAPPS Comparison*
ENSEMBL ID	Gene Symbol*	Description	logFC	Fold Change	P-value	FDR P- value	LogFC	P- value	FDR P-value
First Trimester (CANDLE) – N = 763
ENSG00000168876	ANKRD49	ankyrin repeat domain 49	0.038	1.027	< 0.001	0.039	−0.015	0.168	1.000
ENSG00000015568	RGPD5	RANBP2 like and GRIP domain containing 5	0.108	1.078	< 0.001	0.059	0.111	0.002	1.000
ENSG00000080822	CLDND1	claudin domain containing 1	0.024	1.017	< 0.001	0.059	0.017	0.034	1.000
ENSG00000083828	ZNF586	zinc finger protein 586	0.039	1.027	< 0.001	0.059	−0.021	0.103	1.000
ENSG00000101161	PRPF6	pre-mRNA processing factor 6	−0.024	0.984	< 0.001	0.059	−0.013	0.090	1.000
ENSG00000106404	CLDN15	claudin 15	0.062	1.044	< 0.001	0.059	−0.005	0.845	1.000
ENSG00000110446	SLC15A3	solute carrier family 15 member 3	−0.051	0.965	< 0.001	0.059	0.000	0.984	1.000
ENSG00000116754	SRSF11	serine and arginine rich splicing factor 11	0.029	1.020	< 0.001	0.059	0.009	0.351	1.000
ENSG00000122481	RWDD3	RWD domain containing 3	0.044	1.031	< 0.001	0.059	−0.015	0.269	1.000
ENSG00000134744	TUT4	terminal uridylyl transferase 4	0.028	1.020	< 0.001	0.059	−0.004	0.675	1.000
ENSG00000144026	ZNF514	zinc finger protein 514	0.054	1.038	< 0.001	0.059	−0.010	0.617	1.000
ENSG00000180098	TRNAU1AP	tRNA selenocysteine 1 associated protein 1	0.032	1.022	< 0.001	0.068	−0.003	0.767	1.000
ENSG00000221944	TIGD1	tigger transposable element derived 1	0.043	1.030	< 0.001	0.098	−0.032	0.084	1.000
Second Trimester (CANDLE) – N = 763
ENSG00000116754	SRSF11	serine and arginine rich splicing factor 11	0.038	1.027	< 0.001	0.004	−0.021	0.060	0.774
ENSG00000088448	ANKRD10	ankyrin repeat domain 10	0.084	1.060	< 0.001	0.010	−0.023	0.288	0.860
ENSG00000100353	EIF3D	eukaryotic translation initiation factor 3 subunit D	−0.023	0.984	< 0.001	0.010	0.000	0.946	0.992
ENSG00000102287	GABRE	gamma-aminobutyric acid type A receptor epsilon subunit	0.115	1.083	< 0.001	0.010	−0.088	0.081	0.775
ENSG00000124222	STX16	syntaxin 16	0.034	1.024	< 0.001	0.010	−0.006	0.597	0.928
ENSG00000169217	CD2BP2	CD2 cytoplasmic tail binding protein 2	−0.031	0.979	< 0.001	0.010	−0.005	0.571	0.923
ENSG00000184047	DIABLO	diablo IAP-binding mitochondrial protein	−0.027	0.981	< 0.001	0.018	−0.005	0.476	0.902
ENSG00000163945	UVSSA	UV stimulated scaffold protein A	0.066	1.047	< 0.001	0.026	−0.030	0.241	0.844
ENSG00000122026	RPL21	ribosomal protein L21	−0.032	0.978	< 0.001	0.029	0.008	0.529	0.921
ENSG00000066923	STAG3	stromal antigen 3	0.070	1.050	< 0.001	0.068	−0.023	0.322	0.868
ENSG00000109046	WSB1	WD repeat and SOCS box containing 1	0.036	1.025	< 0.001	0.070	−0.022	0.166	0.832
ENSG00000179010	MRFAP1	Morf4 family associated protein 1	−0.019	0.987	< 0.001	0.070	0.000	0.977	0.999
ENSG00000198727	MT-CYB	mitochondrially encoded cytochrome b	−0.052	0.965	< 0.001	0.070	−0.003	0.903	0.983
ENSG00000198840	MT-ND3	mitochondrially encoded NADH; ubiquinone oxidoreductase core subunit 3	−0.048	0.967	< 0.001	0.070	−0.029	0.205	0.833
ENSG00000167766	ZNF83	zinc finger protein 83	0.058	1.041	< 0.001	0.076	0.015	0.072	0.858
ENSG00000077549	CAPZB	capping actin protein of muscle Z-line subunit beta	−0.018	0.988	< 0.001	0.093	0.006	0.331	0.880
ENSG00000163041	H3–3A	H3.3 histone A	−0.017	0.988	< 0.001	0.093	0.007	0.346	0.880
ENSG00000167978	SRRM2	serine/arginine repetitive matrix 2	0.038	1.027	< 0.001	0.094	−0.006	0.826	0.970
ENSG00000059145	UNKL	unk like zinc finger	0.051	1.036	< 0.001	0.096	−0.030	0.152	0.830
ENSG00000203880	PCMTD2	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2	0.039	1.027	< 0.001	0.098	−0.031	0.049	0.767
First Month (CANDLE) – N = 763
ENSG00000024862	CCDC28A	coiled-coil domain containing 28A	0.019	1.013	< 0.001	0.061	−0.003	0.217	0.975
ENSG00000110446	SLC15A3	solute carrier family 15 member 3	−0.038	0.974	< 0.001	0.061	0.004	0.689	0.960
ENSG00000163634	THOC7	THO complex 7	0.025	1.017	<0.001	0.061	0.014	0.103	0.870

^*Gene symbols and descriptions from HGNC database

^**Only gene hits with FDR < 0.10 in the CANDLE cohort are shown in this table.