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. 2022 Jun 2;82(11):2113–2131.e8. doi: 10.1016/j.molcel.2022.04.027

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© 2022 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

General organization of human CCAN

(A) Scheme of kinetochore organization with CCAN subcomplexes.

(B) Surface model of CENP-16 complex colored to identify distinct sub-modules discussed in the text.

(C) Cartoon model of human CCAN with differently colored chains.

(D) Cartoon model of the S. cerevisiae Ctf19^CCAN with same coloring scheme as for human subunits, as applicable (Hinshaw and Harrison, 2019; Yan et al., 2019).

(E) Cartoon models of human CCAN and yeast Ctf19^CCAN were superposed through CENP-N^Chl4, and the resulting orientation of pillar 2 (CENP-HIKM) was compared. Pillar 2 adopts different orientations in human and yeast CCAN^Ctf19: more divergent in yeast and more parallel to pillar 1 (CENP-OPQUR) in humans. Pillar 1 and the base were removed to enhance clarity. See Figure S10 for further details on structural differences of human CCAN and yeast Ctf19^CCAN.