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. 2022 Jun 24;15(6):dmm049601. doi: 10.1242/dmm.049601

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© 2022. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Distribution of ALDH2 variants in the human population and the impact of ALDH2*2 on human health outcomes. (A) The pie chart displays the prevalence of common ALDH2 variants that cause decreased enzyme activity in East Asian and non-East Asian human populations. (B) The mitochondria schematic shows alcohol metabolism and displays the effects of ALDH2*2 on health. Negative impacts are often mediated by alcohol consumption due to accumulation of acetaldehyde; those in blue font are not mediated by alcohol consumption. ADH, alcohol dehydrogenase; ALDH2, aldehyde dehydrogenase 2; AMeD, aplastic anemia, mental retardation and dwarfism; CVD, cardiovascular disease; HMG-CoA, 3-hydroxy-3-methylglutaryl coenzyme A; WT, wild type.