Table 2.
Colorectal tissue-group comparisons used to identify DMRs associated with colorectal tumorigenesis, normal mucosal aging, and anatomic location of normal mucosa
| Comparisons | Tissue samples compared |
Adjustments for: |
DMR associations c |
||
|---|---|---|---|---|---|
| i | SSLs and cADNs (n=18) |
vs. | SSL- and cADN -paired NM (n=18) |
--- | Colorectal tumorigenesis |
| ii | SSLs (n=10) |
vs. | SSL-paired NM (n=10) |
--- | SSL tumorigenesis |
| iii | cADNs (n=8) |
vs. | cADN-paired NM (n=8) |
--- | cADN tumorigenesis |
| iv | TF-O NM samplesa (n=6) |
vs. | TF-Y NM samplesb (n=6) |
Anatomic location of NM | NM aging |
| v | TF NMCEC samples (n=6) |
vs. | TF NMSIG samples (n=6) |
Age group | Anatomic location of NM |
Abbreviations: cADNs, conventional adenomas; DMR, differentially methylated regions; NM, normal mucosa; NMCEC, NM from the cecum; NMSIG, NM from the sigmoid colon; SSLs, sessile serrated lesions; TF, tumor-free; TF-O, older TF donors (>70 y): TF-Y, younger TF donors (<40 y).
aNMCEC and NMSIG samples from the 3 TF-O donors
bNMCEC and NMSIG samples from the 3 TF-Y donors
cTumorigenesis-specific DMRs were those identified in comparisons i, ii, and/or iii but not in comparisons iv or v