Table 1.

Investigation of Pd Precursors for OAC Formation^a

Entry	Pd Precursor	L	Temp (°C)	Yield A (%)	Yield B (%)
1b	P1	RuPhos	rt	n/a	99
2b	P1	XPhos	rt	n/a	97
3b	P1	t-BuXPhos	rt	n/a	99
4b	P2	RuPhos	rt	n/a	98
5b	P2	XPhos	rt	n/a	99
6b	P2	t-BuXPhos	rt	n/a	40
7	P3	RuPhos	rt	99	0
8	P3	XPhos	rt	70	0
9	P3	t-BuXPhos	rt	0	10
10	P3	t-BuBrettPhos	rt	0	0
11	P3	RuPhos	60	41	59
12	P3	XPhos	60	0	99
13	P3	t-BuXPhos	60	0	82
14	P3	t-BuBrettPhos	60	0	24

^aYields determined by ¹H NMR using 0.5 equiv of 1,3,5-trimethoxybenzene as an internal standard. Reaction conditions: Pd precursor (0.05 mmol), L (0.055 mmol), aryl bromide (0.075 mmol), and THF (0.50 mL, 0.10 M).

^bReactions run for 16 h.