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. 2022 Jun 13;12:922945. doi: 10.3389/fonc.2022.922945

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Copyright © 2022 She, Zhang, Shi, Yang and Dai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of the autotaxin-lysophosphatidic acid signaling pathway. ATX produces the lipid mediator and GPCR agonist lysophosphatidic acid (LPA) from abundantly available extracellular lysophosphatidylcholine (LPC). LPA signal through its six homologous receptors (LPAR1-6) that is binds to G proteins to activate downstream signaling pathways, including those involving Ras/Raf, RhoA, phosphoinositide 3-kinases, mitogen-activated protein kinases, and protein kinase B/mammalian target of rapamycin. The activated LPA-LPAR pathway participates in wound healing, embryonic development, vascular homeostasis, lymphocyte trafficking, cancer biology, stem cell physiology, and therapy resistance, etc.