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Paxillin WT tumor organoid in 3D collagen gels. Tumor organoids in 3D collagen gels demonstrating reduced collective cell invasion in the paxillin KO organoids. Paxillin WT (video 1) and KO tumor organoids (video 2) were cultured for 2 days and then subjected to phase contrast movies. Images were taken every 10 minutes for a total of 8 hours.
