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PLS-NAFLD was derived in a cohort of patients with history of prior NAFLD-associated HCC who underwent curative ablation therapies and validated in HCC-naïve and HCC-experienced patients with NAFLD. PLS-NAFLD was translated to serum protein-based PLSec-NAFLD and validated in an independent cohort of HCC-naïve patients with cirrhosis from NAFLD.
